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KMID : 0361420120360030414
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Journal of Korean Academy of Rehabilitation Medicine
2012 Volume.36 No. 3 p.414 ~ p.417
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Multivessel Thromboembolism Associated with Dysfunction of Protein S
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Ok Eun-Jae
Kim Hye-Won
Kim Sang-Dong
Park Kyoung-Soo
Kim Yang-Soo
Kim Ha-Min
Lim Seong-Hoon
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Abstract
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Protein S is a vitamin K-dependent coagulation factor that acts as an anticoagulant. Deficiency of protein S increases the risk of thromboembolic events. We report a case of isolated protein S deficiency in a 39-year-old woman suffering arterial occlusion in both lower legs. She underwent a surgical procedure using thrombectomy and balloon angioplasty of her left lower extremity. Later, she had right trans-tibial amputation because of the reperfusion injury. Throughout the evaluation of thromboembolic events, we diagnosed a large thrombus in the right atrium and an asymptomatic pulmonary thromboembolism. The patient was successfully treated with right atrial thrombectomy and systemic anticoagulation. Careful evaluation for protein S levels may be necessary in patients with arterial thromboembolic events, especially young adults.
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KEYWORD
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Protein S, Thromboembolism, Trans-tibial amputation
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